A sedentary lifestyle is a behavior that requires non-significant energy expenditure which causes detrimental effects on health that are often not realized. Lifestyle is divided into smoking habits, diet and physical activity. In children, this leads to decreased physical activity which results in obesity. This is a cross sectional, observational analytic study that aims to understand the factors sedentary lifestyle impact on health status of adolescents in Palembang city. We use primary data using questionnaire. There is total of 130 adolescents predominantly within age range of 12-16 years old and majority of females. Bivariate analysis showed that adolescents with a high sedentary lifestyle have 3,33 higher risks of obesity compared to those with moderate sedentary lifestyle (OR=3,33; 95% CI=1,45-7,62). In addition, there is significant association between sedentary lifestyle and blood pressure, in contrast with insignificant relationship with random blood glucose level. The level of physical activity tends to be lower in the older group of adolescents, added with modern lifestyle with all of conveniences, thus the energy that should be spent for physical activity become stored as fat, leading to obesity.