Polycystic ovary syndrome is the most common endocrinopathic disorder in women of
productive age 15-35 years with an incidence rate varying between 1.8%-15%. The exact cause
is still unclear, but environmental involvement and genetic factors are thought to play a role in
the potogenesis of this disease. The purpose of this study was to examine the association 34T/C
polymorphism of CYP17A1 gene with the incidence of polycystic ovary syndrome in
productive age women in Palembang. This research is an observational study with case-control
approach. The population in this study were women of reproductive age who had DNA samples
that had been diagnosed by obstetrics and gynecology specialists at RSIA Rika Amalia
Palembang, both cases and controls. The available samples amounted to 36 for each case -
control group. Genotyping analysis of this study was carried out by PCR-RFLP examination.
The results of 34T/C Genotype Analysis of the CYP17A1 gene in the PCOS case group showed
that the TT (Wildtype) genotype was less (19.4%) than the TC/CC (Mutant) genotype (80.6%),
as well as in the control group the TT (Wildtype) genotype was less (22.2%) than the TC/CC
(Mutant) genotype (77.8%). Allele analysis in the PCOS case group T allele there were (48.7%)
respondents not much different in number from the C allele (51.5%) and in the control group
the T allele was more (51.3%) than the C allele (48.5%). The results of bivariate analysis
showed that the association of 34T/C polymorphism of the CYP17A1 gene with the incidence
of polycystic ovary syndrome was statistically insignificant (OR=1.184; 95% CI= 0.3769-
3.669 with p=0.772). Likewise, the results of the analysis on the T and C alleles showed that
the statistical association between the 34T/C allele polymorphism of the CYP17A1 gene with
polycystic ovary syndrome was not significant (OR = 1.118; CI 95% = 0.580-2.155 with a p
value of 0.738).