The role of placental growth factor as a parameter in preeclampsia: a review of its biomolecular characteristics. Preeclampsia is hypertensive disorder in pregnancy related to 2% to 8% of pregnancy-related complications worldwide. Preeclampsia is diagnosed when blood pressure > 140/90 mmHg after 20 weeks of gestation on two occasions at least 4 hours apart or > 160/100 mmHg in a short interval. Several biomarkers have been identified. One of them is placental growth factor (PlGF) which is a member of the vascular endothelial growth factor family. It is involved in bone marrow‐ derived cell activation, endothelial stimulation, and pathological angiogenesis. Several signaling pathways involve in preeclampsia, such as JAK-STAT signaling pathway. This study aims to review the biomolecular characteristics of PlGF as a parameter in preeclampsia.