Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion or insulin action or both. Diabetes mellitus can be categorized into two types, namely type 1 diabetes mellitus (T1DM) and type 2 (2DM). Type 1 diabetes mellitus (T1DM) is a condition that is often called insulin-dependent DM while T2DM is the opposite. Type 2 diabetes mellitus is mostly characterized by hyperglycemia, relative insulin deficiency, and insulin resistance. In DM conditions, excessive amounts of free radicals will oxidize and degrade lipid components in cell membranes, resulting in lipid peroxidation. As a result of the increase in free radicals, cell membrane lipid peroxidation will also be followed by an increase in the final product called malondialdehyde (MDA) and a decrease in Superoxide Dismutase (SOD). The aim of this literature review is to collect literature related to the effect of flavonoids as antioxidants on blood glucose, serum MDA and SOD levels in diabetes mellitus, in the period 2013-2021. The collection of references obtained is then reviewed and arranged systematically for further discussion. In general, it can be said that flavonoids have an effect as antioxidants which influence blood glucose levels, reduce MDA levels, and increase SOD levels in diabetes mellitus.