Vaginal discharge is one of the problems that is still a problem for most women. Symptoms of vaginal discharge are most often found in gynecological patients; this symptom is known by the patient because of the presence of secret soiling in her pants. Betel leaf decoction can be used to wash the vagina in order to reduce vaginal discharge. The content of betel leaves is essential oil. The content contained in essential oils, one of which is the eugenol compound,. This study used a cross-sectional analytic survey method. The sample in this study were 88 students in the D-III Midwifery study program. Data analysis used in this study is univariate analysis, which describes the dependent variable and the independent variable in order to obtain a description or characteristic of the sample by making a frequency distribution table, and bivariate analysis is used for two variables that are suspected to be related or correlated. The results of the study were obtained from 88 respondents who experienced vaginal discharge, as many as 57 respondents with good knowledge (89.1%), while those who did not experience vaginal discharge were 14 respondents with poor knowledge (58.3%). The results of the Chi-Square statistical test showed that there was a significant relationship between the knowledge of college students about non-pharmacological therapy and the effectiveness of green betel leaf decoction against vaginal discharge, with a p value of 0.02. It is recommended that further research examine the extent of the effectiveness of betel leaf decoction water in treating vaginal discharge.