Corona Virus Disease 19 or Covid-19 is an infectious disease caused by the coronavirus officially named SARS-CoV-2. In December 2019, an outbreak of the COVID-19 disease was first discovered in Wuhan City of China's Hube Province and spread throughout the world. On March 11, 2020, WHO declared Covid-19 a pandemic. COVID-related deaths are largely associated with hypercoagulability and an increased risk of venous thromboembolic events (VTE), leading to thrombotic inflammation in severe conditions.The literature review writing approach used is Systematic Literature Review ( SLR ) with the PRISMA method without meta-analysis. This literature review is carried out to obtain relevant information by searching articles on online databases derived from Scopus. The keywords used for searching related articles are d-dimer, Covid-19, and mortality .Based on the literature study conducted, there are 6 articles that support the discovery of D-Dimer as a predictor of the death of COVID-19 hospitalized patients.The cut off of D-Dimer levels used in each study varied according to the characteristics of the study patients.