Catastrophic diseases are medical conditions that require ongoing care, potentially life-threatening, and incur considerable expenses, experiencing growth predominantly in developing countries and representing substantial burdens to health and economic sectors. Consequently, the objective of this study is to highlight the impacts of catastrophic diseases in Indonesia, while identifying the risk factors, and potentially offering valuable strategies for family physicians aiming to mitigate these challenges. The disease burdens, such as prevalence, death, DALYs, ASDR and associated risk factors, were collected from Global Burden of Disease (GBD) 2021 during June to 5^th July 2024. Furthermore, information on the financial implications was extracted from the Indonesian Social Security Agency for Health. The Indonesian majority of DALYs were contributed by cardiovascular disease while except for cancers, the other diseases exhibited higher mortality rate compared to the global ASDR. Additionally, there were notable increases in diseases prevalence between 2010 and 2021, hence majority of catastrophic diseases securing the third position worldwide in terms of DALYs. There has been a consistent rise in the caseloads and healthcare costs since 2018 till 2022. Moreover, several risk factors have been identified such as elevated BP, FPG, and smoking underscoring the necessity for intervention including smoking ban, promoting healthy dietary and lifestyle. In recent decade, catastrophic diseases have led to significant health and economic burdens across Indonesia. As a result, it is imperative to implement preventive measures to mitigate these challenges which create opportunities for family doctors to address these gaps in healthcare system.