Majalah Kedokteran Sriwijaya

THE EFFECT OF RESVERATROL ADDITION ON IMPROVEMENT OF GLOBAL LONGITUDINAL STRAIN IN TYPE 2 DIABETES MELLITUS PATIENTS AT DR. MOHAMMAD HOESIN HOSPITAL PALEMBANG

Ahmad Khaeril Irfan; Taufik Indrajaya Sari, Yulianto Kusnadi, Legiran — Thu, 29 Jan 2026 00:00:00 +0000

Type 2 diabetes mellitus (T2DM) increases the risk of myocardial fibrosis, which contributes to cardiovascular complications. The prevalence of myocardial fibrosis in diabetic patients ranges from 15–62% based on a meta-analysis. Global Longitudinal Strain (GLS) assessment with Speckle Tracking Echocardiography (STE) can detect myocardial fibrosis non-invasively, with GLS < -21% to rule out fibrosis and GLS > -15% to diagnose fibrosis. Resveratrol, a natural polyphenol, is known to have cardioprotective effects; however, clinical evidence in T2DM patients is still limited to animal studies. This study aims to evaluate the effectiveness of resveratrol administration on improving cardiac fibrosis as measured by GLS in T2DM patients.This study was a double-blind randomized controlled trial in T2DM patients with GLS <21% at Dr. Mohammad Hoesin Hospital Palembang (June–November 2025). A total of 32 subjects were divided into two groups (16 each) using block permuted randomization: an intervention group and a control group for 12 weeks. Outcomes measured included changes in GLS, EF, and IVSD. Data analysis was performed using SPSS 29.Of the 40 subjects, 12 dropped out. In the analyzed subjects (14 per group), resveratrol administration for 12 weeks reduced GLS more than placebo (mean difference -1.92% vs -0.74%; p=0.006) and increased EF (mean difference +3.35% vs -4.2%; p=0.003), while IVSD did not change significantly. Resveratrol was shown to be an independent predictor of GLS and EF improvement in multivariate analysis. Mild side effects (bloating) were reported in 14.8% of resveratrol subjects.Resveratrol significantly improves GLS and EF in T2DM patients but does not affect IVSD. Resveratrol has potential as a long-term adjunctive therapy.

ANIMATED VIDEOS' IMPACT ON INCREASING ANEMIA KNOWLEDGE

Toto Harto; Berta Afriani, Dimas Ardiyansyah , Roni Ferdi — Fri, 30 Jan 2026 00:00:00 +0000

Anemia is a global health problem caused by iron deficiency in adolescent girls. Health education using educational media such as animated videos is an effective method for improving students' understanding of anemia. This study aims to determine the effect of female students' knowledge on the effectiveness of animated videos about anemia. A quasi-experimental design with a pre-test and post-test approach was used. The research sample consisted of 47 people selected through total sampling. Data were collected using questionnaires to measure knowledge levels before and after the animated video intervention. Data analysis was performed using a paired t-test to determine the difference in knowledge levels before and after the intervention. The results showed a significant increase in students' knowledge levels after the animated video intervention (p value = 0.000). This indicates that animated videos are an effective educational medium for improving students' understanding of anemia. These findings also show that audiovisual media can attract students' attention and improve their memory of the material presented. Therefore, it is recommended that health education institutions use animated videos as educational tools to increase students' awareness and knowledge about anemia, and apply them in broader health promotion efforts.

PEDIATRIC MASSIVE TRANSFUSION SAFETY STRATEGY

Dini Meta Rica; Elizeus Hanindito, Arie Utariani Sari — Fri, 30 Jan 2026 00:00:00 +0000

Pediatric massive transfusion is a time-critical intervention in which uncontrolled hemorrhage may rapidly causing developmental hemostatic differences, dilutional coagulopathy, hypothermia, acidosis, and electrolyte disturbance, leading to substantial morbidity and mortality. In contrast to adult practice, pediatric transfusion management remains less standardized, and bedside decisions are still frequently influenced by extrapolated evidence, local protocols, and clinician judgment. This review aimed to summarize a practical, safety-oriented approach to pediatric massive transfusion, with emphasis on perioperative assessment, monitoring, activation criteria, transfusion protocols, and prevention of transfusion-related complications.We performed a narrative review of literature published between 2018 and 2026. Priority was given clinical practice guidelines, expert consensus documents, systematic reviews, and clinically relevant observational studies addressing pediatric major hemorrhage, trauma, cardiac surgery, extracorporeal support, viscoelastic testing, tranexamic acid, whole blood, and patient blood management. Evidence was selected for clinical relevance to perioperative anesthesia practice and synthesized theme.Safe pediatric massive transfusion requires early recognition of major bleeding, timely protocol activation, balanced and goal-directed blood product delivery, close hemodynamic and hemostatic reassessment, and active prevention of predictable metabolic and transfusion-related complications. Overall, the current literature supports a restrictive, physiology-guided approach while underscoring the need for stronger prospective pediatric evidence

RAPIDLY PROGRESSIVE MENINGEAL MELANOMATOSIS PRESENTING DURING PREGNANCY: A RARE AND AGGRESSIVE ENTITY

Yunni Diansari, Rizka Aprillia Syahputri; Aspitriani, Hanna Marsinta Uli Sari — Fri, 30 Jan 2026 00:00:00 +0000

Meningeal melanomatosis is an extremely rare and aggressive melanocytic neoplasm of the central nervous system characterized by diffuse leptomeningeal involvement. Its occurrence during pregnancy is exceptionally uncommon and presents significant diagnostic and therapeutic challenges. A 39-year-old woman at 15 weeks of gestation presented with progressive headache and left-sided weakness. Brain MRI revealed a right frontal extra-axial mass with surrounding edema and subfalcine herniation. Surgical resection was performed due to neurological deterioration. Histopathological and immunohistochemical analysis confirmed malignant melanoma (S100-positive, HMB-45-positive, high Ki-67 index). Postoperative MRI demonstrated residual extra-axial mass suspicious for meningeal melanomatosis. Focal radiotherapy (20 Gy) was administered. The patient subsequently experienced spontaneous preterm delivery. Four months later, bilateral breast metastases were identified. Progressive neurological decline occurred, and the patient died eight months after initial diagnosis.Meningeal melanomatosis during pregnancy represents a rare and highly aggressive condition with poor prognosis despite multimodal treatment.

Keywords: Meningeal melanomatosis; Pregnancy; melanoma

Ecological Dominance, Biting Behavior, and Molecular Detection of Brugia malayi in Culex quinquefasciatus from Filariasis Endemic Wetlands of South Sumatra, Indonesia

Rini Pratiwi, Peni Kusumasari, Fitriyanti, Dalilah — Tue, 14 Apr 2026 00:00:00 +0000

Lymphatic filariasis (LF) remains endemic in Indonesian wetland ecosystems despite long-term mass drug administration (MDA). Environmental modification may alter mosquito community structure and promote the emergence of alternative vector species. A longitudinal entomological survey was conducted in two endemic villages in Banyuasin Regency, South Sumatra. Adult mosquitoes were collected using indoor and outdoor human landing collections and resting collections. Ecological indices, including abundance, dominance, man-hour density (MHD), and man-biting rate (MBR), were calculated. Molecular detection of Brugia malayi was performed using PCR targeting the yACA gene, followed by sequencing confirmation. A total of 1,342 female Culex mosquitoes representing eight species were collected. Culex quinquefasciatus was overwhelmingly dominant (92.4%), particularly in Muara Sugih Village, and exhibited marked endophagic and endophilic behavior. Biting density and MBR were substantially higher in Muara Sugih than in Sedang Village. PCR and sequencing confirmed the presence of B. malayi DNA in Cx. quinquefasciatus. The ecological dominance, indoor feeding behavior, and molecular evidence of B. malayi infection in Cx. quinquefasciatus suggest its potential role as a supplementary vector in modified wetland ecosystems. Integration of ecological surveillance and molecular xenomonitoring is essential to detect residual transmission and support LF elimination in post-MDA settings.